Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 17/20 | 0.56 |
| ▸ | CNR2 | P34972 | 5/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215181 | 0.91 | CNR1 (0.56) | CNR1CNR2TRPV1 | |
| SCHEMBL14856839 | 0.89 | CNR1 (0.51) | CNR1CNR2NTRK1 | |
| SCHEMBL211995 | 0.88 | CNR1 (0.56) | CNR1CNR2TRPV1 | |
| SCHEMBL531063 | 0.87 | CNR1 (0.60) | CNR1CNR2 | |
| SCHEMBL212405 | 0.86 | CNR1 (0.61) | CNR1CNR2TRPV1 | |
| SCHEMBL214132 | 0.85 | CNR1 (0.51) | CNR1CNR2NTRK1TRPV1 | |
| SCHEMBL214846 | 0.84 | CNR1 (0.49) | CNR1CNR2 | |
| SCHEMBL1017595 | 0.82 | KMO (0.44) | — | |
| SCHEMBL214825 | 0.81 | CNR1 (0.40) | CNR1CNR2NTRK1TRPV1 | |
| SCHEMBL14856853 | 0.80 | CNR1 (0.51) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | claimed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |