Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856820 | 0.90 | CNR1 (0.44) | CNR1MEN1KMT2APIK3CACNR2 | |
| SCHEMBL212800 | 0.89 | CNR1 (0.51) | CNR1CNR2HDAC4HDAC6 | |
| SCHEMBL214387 | 0.87 | CNR1 (0.61) | CNR1CNR2 | |
| SCHEMBL212455 | 0.86 | CNR1 (0.46) | CNR1CNR2HDAC4HDAC6GABRA5 | |
| SCHEMBL213702 | 0.84 | CNR1 (0.56) | CNR1CNR2 | |
| SCHEMBL4064494 | 0.83 | MEN1 (0.45) | MEN1KMT2APIK3CA | |
| SCHEMBL215181 | 0.83 | CNR1 (0.56) | CNR1CNR2CHRM1 | |
| SCHEMBL212749 | 0.82 | MEN1 (0.41) | CNR1MEN1KMT2APIK3CACNR2 | |
| SCHEMBL14856737 | 0.77 | CNR1 (0.46) | CNR1CNR2HDAC4HDAC6 | |
| SCHEMBL14856867 | 0.76 | CNR1 (0.56) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |