Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 14/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 4/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21372652 | 0.84 | IDO1 (0.39) | IDO1CAMKK2PBKTDO2 | |
| SCHEMBL21372840 | 0.84 | IDO1 (0.57) | IDO1 | |
| SCHEMBL21372682 | 0.83 | IDO1 (0.52) | IDO1TDO2 | |
| SCHEMBL21372927 | 0.81 | IDO1 (0.47) | IDO1TDO2 | |
| SCHEMBL21373045 | 0.81 | IDO1 (0.42) | IDO1 | |
| SCHEMBL21373039 | 0.80 | IDO1 (0.41) | IDO1PBKTDO2 | |
| SCHEMBL21372968 | 0.80 | IDO1 (0.41) | IDO1TDO2 | |
| SCHEMBL18224816 | 0.80 | CAMKK2 (0.39) | CAMKK2PBK | |
| SCHEMBL18236920 | 0.80 | CAMKK2 (0.39) | CAMKK2PBK | |
| SCHEMBL18224817 | 0.80 | CAMKK2 (0.39) | CAMKK2PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294732-B1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES INC (US) | 2019-09-25 | — | — | EP | claimed |