Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21909808 | 0.86 | MAPT (0.58) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL21376521 | 0.84 | SCD (0.62) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL21909790 | 0.83 | MAPT (0.57) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL29978060 | 0.82 | MAPT (1.00) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL662501 | 0.82 | MAPT (1.00) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL21376342 | 0.81 | MAPT (0.70) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL21376799 | 0.81 | SCD (0.60) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL21376914 | 0.79 | SMN1; SMN2 (0.64) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL21909758 | 0.76 | NPC1 (0.51) | MAPTSMN1; SMN2KMT2AALDH1A1NPC1 | |
| SCHEMBL5713530 | 0.76 | MAP3K5 (0.75) | MAPTSMN1; SMN2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626240-A1 | PROCESS OF PREPARATION OF A N-ARYL BENZYL SULFONAMIDE SUBSTITUTED WITH AN AMIDO GROUP | StemSynergy Therapeutics, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |
| EP-2403499-B1 | METHODS AND COMPOSITIONS FOR USE IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS INC (US) | 2019-09-18 | — | — | EP | disclosed |