Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NAMPT | P43490 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | PHGDH | O43175 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SCD | O00767 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21909747 | 0.89 | NPC1 (0.57) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL26835068 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2NAMPTLMNAPHGDHMEN1 | |
| SCHEMBL663770 | 0.81 | SMN1; SMN2 (0.90) | SMN1; SMN2NAMPTLMNAPHGDHMEN1 | |
| SCHEMBL29978651 | 0.81 | SMN1; SMN2 (0.90) | SMN1; SMN2NAMPTLMNAPHGDHMEN1 | |
| SCHEMBL21376507 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2NAMPTLMNAPHGDHMEN1 | |
| SCHEMBL21376351 | 0.78 | LMNA (0.50) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL21376606 | 0.77 | NR2F2 (0.48) | SMN1; SMN2NAMPTMEN1KMT2AKDM4E | |
| SCHEMBL21376339 | 0.77 | MAPT (0.56) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL21376342 | 0.76 | MAPT (0.70) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL21376333 | 0.76 | NPC1 (0.57) | SMN1; SMN2LMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-B1 | METHODS AND COMPOSITIONS FOR USE IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS INC (US) | 2019-09-18 | — | — | EP | disclosed |