Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22663366 | 0.90 | HRH3 (0.40) | HRH3GNAI3GNAO1GNAI1SLC6A4 | |
| SCHEMBL22890953 | 0.87 | GNAI3 (0.34) | HRH3GNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL22890929 | 0.85 | HRH3 (0.41) | HRH3SIGMAR1MAOBALDH1A1KCNH2 | |
| SCHEMBL20698611 | 0.84 | HRH3 (0.43) | HRH3GNAI3GNAO1GNAI1SLC6A4 | |
| SCHEMBL13543410 | 0.82 | MEN1 (0.46) | HRH3MAOBALDH1A1 | |
| SCHEMBL21733612 | 0.81 | ALDH1A1 (0.51) | HRH3SIGMAR1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL13543156 | 0.81 | MEN1 (0.45) | HRH3MAOBALDH1A1 | |
| SCHEMBL22861349 | 0.80 | MEN1 (0.38) | HRH3SLC6A4MAOBCYP1A2CHRM2 | |
| SCHEMBL20739270 | 0.80 | HRH3 (0.44) | HRH3SLC6A4SIGMAR1ALDH1A1CYP1A2 | |
| SCHEMBL21348409 | 0.80 | ALDH1A1 (0.47) | HRH3SIGMAR1ALDH1A1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10568874-B2 | Indane-amines as PD-L1 antagonists | CHEMOCENTRYX, INC. (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190282555-A1 | INDANE-AMINES AS PD-L1 ANTAGONISTS | CHEMOCENTRYX, INC. | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190282555-A1 | INDANE-AMINES AS PD-L1 ANTAGONISTS | CD274, PDCD1LG2, PDCD1 | HRH3 11/4885GNAI3 1607/4885GNAO1 1080/4885 |
| US-10568874-B2 | Indane-amines as PD-L1 antagonists | CD274, PDCD1LG2, PDCD1 | HRH3 11/4885GNAI3 1607/4885GNAO1 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.