Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | MMP9 | P14780 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20271939 | 1.00 | LMNA (0.58) | LMNAALDH1A1SMN1; SMN2GAAMMP2 | |
| SCHEMBL21378114 | 0.86 | LMNA (0.61) | LMNAALDH1A1SMN1; SMN2GAAMMP2 | |
| SCHEMBL20271521 | 0.86 | LMNA (0.61) | LMNAALDH1A1SMN1; SMN2GAAMMP2 | |
| SCHEMBL21378122 | 0.84 | MMP2 (0.69) | LMNAALDH1A1MMP2MMP9TSHR | |
| SCHEMBL21378115 | 0.79 | BRD4 (0.78) | LMNAALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL20271590 | 0.79 | BRD4 (0.78) | LMNAALDH1A1SMN1; SMN2GAATSHR | |
| SCHEMBL16763315 | 0.77 | MMP2 (0.61) | ALDH1A1MMP2MMP9MAPTMAPK1 | |
| SCHEMBL16763314 | 0.77 | MMP2 (0.61) | ALDH1A1MMP2MMP9MAPTMAPK1 | |
| SCHEMBL3720939 | 0.76 | MMP2 (0.60) | ALDH1A1MMP2MMP9HTTPOLB | |
| SCHEMBL26616350 | 0.76 | MMP2 (0.60) | ALDH1A1MMP2MMP9HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-14 | — | — | US | disclosed |
| US-10975059-B2 | Small molecule BRD4 modulators for HIV epigenetic regulation | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190292168-A1 | NOVEL SMALL MOLECULE BRD4 MODULATORS FOR HIV EPIGENETIC REGULATION | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975059-B2 | Small molecule BRD4 modulators for HIV epigenetic regulation | BRD4, BICRA, BRD3 | LMNA 3677/4885ALDH1A1 4499/4885SMN1; SMN2 4476/4885 |
| US-20190292168-A1 | NOVEL SMALL MOLECULE BRD4 MODULATORS FOR HIV EPIGENETIC REGULATION | BRD4, BICRA, BRD3 | LMNA 3706/4885ALDH1A1 4553/4885SMN1; SMN2 4485/4885 |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BRD4, NFKBIA, NFRKB | LMNA 1955/4885ALDH1A1 4628/4885SMN1; SMN2 3064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.