Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 7/20 | 0.96 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.96 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.96 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.96 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.96 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.96 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.96 |
| ▸ | GABRP | O00591 | 1/20 | 0.96 |
| ▸ | GABRD | O14764 | 1/20 | 0.96 |
| ▸ | IKBKB | O14920 | 1/20 | 0.96 |
| ▸ | AURKA | O14965 | 1/20 | 0.96 |
| ▸ | PIM1 | P11309 | 1/20 | 0.96 |
| ▸ | TOP1 | P11387 | 1/20 | 0.96 |
| ▸ | IDO1 | P14902 | 1/20 | 0.96 |
| ▸ | HPGD | P15428 | 1/20 | 0.96 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.96 |
| ▸ | MAOA | P21397 | 1/20 | 0.96 |
| ▸ | MAOB | P27338 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norharmane SCHEMBL28243496 | 1.00 | CHUK (0.96) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL9486853 | 0.98 | CHUK (1.00) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL29370219 | 0.98 | CHUK (1.00) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Carbazole SCHEMBL18684843 | 0.98 | CHUK (1.00) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL25834 | 0.98 | CHUK (1.00) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL11561251 | 0.96 | CHUK (0.96) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL8686167 | 0.96 | CHUK (0.96) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL8683826 | 0.96 | CHUK (0.96) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL29809643 | 0.96 | CHUK (0.96) | CHUKGABRA1GABRG2GABRB3GABRA5 | |
| Norharmane SCHEMBL28902872 | 0.96 | CHUK (0.96) | CHUKGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829491-B2 | Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACAD (CN) | 2020-11-10 | — | — | US | claimed |
| EP-3546460-B1 | PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2020-07-08 | — | — | EP | claimed |
| EP-3546460-A1 | PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-10-02 | — | — | EP | claimed |
| US-20190292183-A1 | PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-09-26 | — | — | US | claimed |
| US-10829491-B2 | Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACAD (CN) | 2020-11-10 | — | — | US | disclosed |
| EP-3546460-B1 | PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2020-07-08 | — | — | EP | disclosed |
| EP-3546460-A1 | PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-10-02 | — | — | EP | disclosed |
| US-20190292183-A1 | PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292183-A1 | PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF | BTK, SYK, CDK8 | CHUK 264/4885GABRA1 2346/4885GABRG2 2107/4885 |
| US-10829491-B2 | Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof | BTK, SYK, CDK8 | CHUK 264/4885GABRA1 2346/4885GABRG2 2107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.