Norharmane

Norharmane

SCHEMBL29370219

c1ccc2c(c1)[nH]c1cnccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHUK O15111 7/20 1.00
GABRA1 P14867 2/20 1.00
GABRG2 P18507 2/20 1.00
GABRB3 P28472 2/20 1.00
GABRA5 P31644 2/20 1.00
GABRA3 P34903 2/20 1.00
GABRA2 P47869 2/20 1.00
ALDH1A1 P00352 2/20 1.00
KDM4E B2RXH2 1/20 1.00
GABRP O00591 1/20 1.00
GABRD O14764 1/20 1.00
IKBKB O14920 1/20 1.00
AURKA O14965 1/20 1.00
PIM1 P11309 1/20 1.00
TOP1 P11387 1/20 1.00
IDO1 P14902 1/20 1.00
HPGD P15428 1/20 1.00
GABRB1 P18505 1/20 1.00
MAOA P21397 1/20 1.00
MAOB P27338 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Norharmane SCHEMBL9486853 1.00 CHUK (1.00) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL25834 1.00 CHUK (1.00) CHUKGABRA1GABRG2GABRB3GABRA5
Carbazole SCHEMBL18684843 1.00 CHUK (1.00) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL11561251 0.98 CHUK (0.96) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL21378153 0.98 CHUK (0.96) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL8683826 0.98 CHUK (0.96) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL30013210 0.98 CHUK (0.96) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL8686167 0.98 CHUK (0.96) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL29809643 0.98 CHUK (0.96) CHUKGABRA1GABRG2GABRB3GABRA5
Norharmane SCHEMBL29217000 0.98 CHUK (0.96) CHUKGABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 438 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137652-A1 Composition Comprising Non-Phosphorylated Tryptamine SINTALICA S R L (IT) 2026-05-21 US claimed
US-20260091047-A1 THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS NATIVE CODE BIO LLC (US) 2026-04-02 US claimed
US-20260069538-A1 CXCR4 ANTAGONIST LOADED LIPOSOMES AND SILICASOMES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-03-12 US claimed
US-20260049115-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER WITH ECM-AFFINITY PEPTIDES LINKED TO CYTOKINES THE UNIVERSITY OF CHICAGO (US) 2026-02-19 US claimed
EP-4646433-A1 ANTI-IL-18BP ANTIBODIES Lassen Therapeutics, Inc. (US) 2025-11-12 EP claimed
EP-4646432-A1 ANTI-IL-18BP ANTIBODIES Lassen Therapeutics, Inc. (US) 2025-11-12 EP claimed
US-20250339403-A1 Tryptamine Formulations and Uses Thereof Natural MedTech Pty Ltd (AU) 2025-11-06 US claimed
EP-4638788-A1 ANALYSIS OF ANALYTES AND SPATIAL GENE EXPRESSION 10X Genomics, Inc. (US) 2025-10-29 EP claimed
EP-4638419-A1 NON-HALLUCINOGENIC TRYPTAMINE COMPOUNDS, PREPARATION, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Sintalica S.r.l. (IT) 2025-10-29 EP claimed
US-12453720-B2 Application of norharmane in improving antibacterial activity of antibiotics ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) 2025-10-28 US claimed
EP-4229416-A1 METHOD FOR DETECTION OF ANALYTES IN A SINGLE TISSUE SAMPLE FROM ITO SLIDES USING MSI-LCM Universiteit Maastricht (NL) 2023-08-23 EP claimed
CN-116270626-A Application of nor Ha Erman in preparation of antibacterial agent 浙江工业大学 2023-06-23 CN claimed
WO-2023081514-A1 CXCR4 ANTAGONIST LOADED LIPOSOMES AND SILICASOMES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-05-11 WO claimed
WO-2023076998-A1 COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2a ANTIBODIES ATYR PHARMA, INC. (US) 2023-05-04 WO claimed
CN-114288291-B Application of Norharman in preparation of medicine for preventing or treating acute pancreatitis 大连医科大学附属第一医院 2023-04-28 CN claimed
US-20220304988-A1 AN APPLICATION OF NORHARMANE IN IMPROVING ANTIBACTERIAL ACTIVITY OF ANTIBIOTICS ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) 2022-09-29 US claimed
EP-4037711-A1 COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2 ANTIBODIES Atyr Pharma, Inc. (US) 2022-08-10 EP claimed
WO-2022094132-A1 A SILICASOME NANOCARRIER FOR METAL-BASED DRUG DELIVERY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-05-05 WO claimed
WO-2022079084-A1 METHOD FOR DETECTION OF ANALYTES IN A SINGLE TISSUE SAMPLE FROM ITO SLIDES USING MSI-LCM UNIVERSITEIT MAASTRICHT (NL) 2022-04-21 WO claimed
CN-107290452-B Method for detecting content of bound heterocyclic amine 江南大学 2022-04-15 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220304988-A1 AN APPLICATION OF NORHARMANE IN IMPROVING ANTIBACTERIAL ACTIVITY OF ANTIBIOTICS NRDC, MGAM, GALE CHUK 1933/4885GABRA1 2797/4885GABRG2 3615/4885
US-20260091047-A1 THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS HMBS, SNCA, PYGB CHUK 3736/4885GABRA1 667/4885GABRG2 1588/4885
US-20260049115-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER WITH ECM-AFFINITY PEPTIDES LINKED TO CYTOKINES FN1, MATR3, COL14A1 CHUK 3684/4885GABRA1 2593/4885GABRG2 3047/4885
US-20260137652-A1 Composition Comprising Non-Phosphorylated Tryptamine HTR2B, BDNF, HTR3B CHUK 1809/4885GABRA1 280/4885GABRG2 748/4885
US-20260069538-A1 CXCR4 ANTAGONIST LOADED LIPOSOMES AND SILICASOMES CXCL12, CXCR4, CXCR5 CHUK 650/4885GABRA1 2384/4885GABRG2 3393/4885
US-12453720-B2 Application of norharmane in improving antibacterial activity of antibiotics NRDC, NOTUM, MGAM CHUK 2109/4885GABRA1 3103/4885GABRG2 3615/4885
US-20250339403-A1 Tryptamine Formulations and Uses Thereof MAOA, MAOB, TPH1 CHUK 2078/4885GABRA1 2398/4885GABRG2 2899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.