Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20379417 | 0.88 | SMN1; SMN2 (0.54) | SIGMAR1MAPTTSHRKDM4EMEN1 | |
| SCHEMBL21381476 | 0.86 | SMN1; SMN2 (0.53) | MAPTTSHRKDM4EMEN1CASP1 | |
| SCHEMBL20379410 | 0.85 | SMN1; SMN2 (0.53) | MAPTTSHRKDM4EMEN1CASP1 | |
| SCHEMBL21381478 | 0.85 | THRB (0.52) | SIGMAR1MAPTTSHRKDM4EMEN1 | |
| SCHEMBL20379084 | 0.85 | MAPT (0.47) | SIGMAR1MAPTTSHRKDM4EMEN1 | |
| SCHEMBL28331412 | 0.83 | TRPV6 (0.48) | TRPV6SIGMAR1MAPTTSHRKDM4E | |
| SCHEMBL21373574 | 0.83 | SMN1; SMN2 (0.47) | MAPTTSHRKDM4EMEN1CASP1 | |
| SCHEMBL20379088 | 0.82 | TSHR (0.50) | TRPV6SIGMAR1MAPTTSHRKDM4E | |
| SCHEMBL21373558 | 0.79 | BRD9 (0.40) | TRPV6MAPTTSHRKDM4ECMA1 | |
| SCHEMBL20379164 | 0.78 | TRPV6 (0.47) | TRPV6SIGMAR1MAPTTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768673-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2021-01-27 | — | — | EP | claimed |
| WO-2019179890-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH ZURICH (CH) | 2019-09-26 | — | — | WO | claimed |
| EP-3768673-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019179890-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH ZURICH (CH) | 2019-09-26 | — | — | WO | disclosed |