Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11865607 | 0.84 | ALDH1A1 (0.33) | ALOX15ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL17608657 | 0.70 | MGAM (0.48) | ALOX15ALDH1A1HPGDHSD17B10MGAM | |
| SCHEMBL21383793 | 0.69 | CCNE2 (0.31) | CCNE2CCNE1CDK2 | |
| SCHEMBL27158053 | 0.69 | ALOX15 (0.50) | ALOX15ALDH1A1HPGDHSD17B10AKR1B1 | |
| SCHEMBL6317502 | 0.69 | ALOX15 (0.50) | ALOX15ALDH1A1HPGDHSD17B10AKR1B1 | |
| SCHEMBL17443543 | 0.68 | KDM4E (0.41) | ALOX15ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL9903279 | 0.68 | ALDH1A1 (0.49) | ALOX15ALDH1A1HPGDHSD17B10AKR1B1 | |
| SCHEMBL30899548 | 0.68 | ALOX15 (0.62) | ALOX15ALDH1A1HPGDHSD17B10MGAM | |
| SCHEMBL11617994 | 0.68 | ALOX15 (0.62) | ALOX15ALDH1A1HPGDHSD17B10MGAM | |
| SCHEMBL5254858 | 0.68 | KDM4E (0.41) | ALOX15ALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768680-A1 | PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183364-A1 | PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |