Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2138401 | 1.00 | FNTA (0.41) | FNTAFNTBTHRBPGGT1BKDM4C | |
| SCHEMBL4476345 | 0.77 | EPHX1 (0.47) | KDM4CEPHX2EPHX1MAPTKDM4E | |
| SCHEMBL15175034 | 0.74 | KDM4C (0.41) | KDM4CEPHX2EPHX1MAPTKDM4E | |
| SCHEMBL196214 | 0.73 | EPHX1 (0.50) | KDM4CEPHX2EPHX1MAPTKDM4E | |
| SCHEMBL1964189 | 0.71 | EPHX1 (0.48) | KDM4CEPHX2EPHX1MAPTKDM4E | |
| SCHEMBL22655250 | 0.71 | KDM4E (0.46) | KDM4CEPHX2EPHX1MAPTKDM4E | |
| SCHEMBL2834332 | 0.71 | EPHX1 (0.52) | KDM4CEPHX2EPHX1MAPTKDM4E | |
| SCHEMBL3279679 | 0.69 | MMP1 (0.41) | FNTAFNTBTHRBPGGT1BKDM4C | |
| SCHEMBL319971 | 0.67 | EPHX1 (0.71) | KDM4CEPHX2EPHX1MAPTKDM4E | |
| SCHEMBL30943103 | 0.67 | EPHX1 (0.55) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148414-B2 | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use | XENOPORT, INC. (US) | 2012-04-03 | — | — | US | disclosed |