Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433779 | 0.86 | TRPV1 (0.50) | TRPV1HSD11B1KMT2AMEN1GAA | |
| SCHEMBL5693374 | 0.81 | TRPA1 (0.64) | TRPV1TRPA1 | |
| SCHEMBL20139820 | 0.81 | HSD11B1 (0.48) | TRPV1HSD11B1KMT2ATRPA1GAA | |
| SCHEMBL20339483 | 0.81 | TRPV1 (0.61) | TRPV1HSD11B1KMT2AGAAALDH1A1 | |
| SCHEMBL20140927 | 0.80 | CA1 (0.47) | TRPV1HSD11B1KMT2ATRPA1GAA | |
| SCHEMBL1433068 | 0.79 | POLB (0.56) | TRPV1TRPA1 | |
| SCHEMBL30591901 | 0.79 | POLB (0.56) | TRPV1TRPA1 | |
| SCHEMBL10318897 | 0.79 | HSD11B1 (0.46) | TRPV1HSD11B1KMT2ATRPA1GAA | |
| SCHEMBL4879872 | 0.79 | KDM4E (0.60) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL20406252 | 0.78 | CYP1A2 (0.53) | TRPV1KMT2AMEN1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768669-A1 | PIPERAZINE AZASPIRO DERIVAVES | Pfizer Inc (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183636-A1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER INC. (US) | 2019-09-26 | — | — | WO | disclosed |