Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21682372 | 0.90 | CYP2D6 (0.49) | CYP2D6CYP1A2ALDH1A1HPGDNPSR1 | |
| SCHEMBL22915091 | 0.88 | CYP2D6 (0.46) | CYP2D6CYP1A2ALDH1A1POLBNPSR1 | |
| SCHEMBL21401566 | 0.88 | CYP2D6 (0.46) | CYP2D6CYP1A2ALDH1A1POLBNPSR1 | |
| SCHEMBL24802905 | 0.86 | CYP2D6 (0.45) | CYP2D6RORCTP53KMT2A | |
| SCHEMBL751833 | 0.86 | CYP2D6 (0.48) | CYP2D6CYP1A2ALDH1A1POLBNR1I2 | |
| SCHEMBL23453563 | 0.79 | CYP2D6 (0.49) | CYP2D6CYP1A2RORCTP53KMT2A | |
| SCHEMBL196226 | 0.78 | CYP2D6 (0.67) | CYP2D6CYP1A2ALDH1A1POLBHPGD | |
| SCHEMBL21987575 | 0.78 | CYP2D6 (0.55) | CYP2D6CYP1A2ALDH1A1POLBHPGD | |
| SCHEMBL21384491 | 0.78 | ABHD6 (0.32) | FAAHMGLLABHD6 | |
| SCHEMBL27129692 | 0.78 | ABHD6 (0.32) | FAAHMGLLABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219464-A1 | PIPERAZINE AZASPIRO DERIVAVES | Pfizer Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20230192654-A1 | PIPERAZINE AZASPIRO DERIVATIVES | PFIZER INC. | 2023-06-22 | — | — | US | disclosed |
| EP-3768669-B1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER (US) | 2023-01-25 | — | — | EP | disclosed |
| US-11524954-B2 | Piperazine azaspiro derivatives | PFIZER INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210024497-A1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER INC. | 2021-01-28 | — | — | US | disclosed |
| EP-3768669-A1 | PIPERAZINE AZASPIRO DERIVAVES | Pfizer Inc (US) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019183636-A1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER INC. (US) | 2019-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192654-A1 | PIPERAZINE AZASPIRO DERIVATIVES | CHRM1, CHRM2, CHRM5 | CYP2D6 360/4885CYP1A2 87/4885ALDH1A1 1350/4885 |
| US-11524954-B2 | Piperazine azaspiro derivatives | CHRM1, CHRM2, CHRM5 | CYP2D6 360/4885CYP1A2 87/4885ALDH1A1 1350/4885 |
| US-20210024497-A1 | PIPERAZINE AZASPIRO DERIVAVES | CHRM1, CHRM2, CHRM5 | CYP2D6 259/4885CYP1A2 78/4885ALDH1A1 906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.