Sugi Predict

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SCHEMBL22915091

SCHEMBL22915091

CCOC(=O)N1CC2(CC[C@H](OS(=O)(=O)c3ccc(C)cc3)C2)C1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ ALDH1A1 P00352 4/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ NPSR1 Q6W5P4 2/20 0.42
▸ TP53 P04637 1/20 0.42
▸ ALOX15 P16050 1/20 0.42
▸ MAPK1 P28482 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ LMNA P02545 1/20 0.41
▸ POLB P06746 1/20 0.41
▸ APP P05067 4/20 0.40
▸ CYP1A2 P05177 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21401566 1.00 CYP2D6 (0.46) CYP2D6KMT2AALDH1A1KDM4ENPSR1
SCHEMBL21384392 0.88 CYP2D6 (0.48) CYP2D6KMT2AALDH1A1NPSR1TP53
SCHEMBL24802905 0.87 CYP2D6 (0.45) CYP2D6KMT2ATP53MEN1
SCHEMBL30003332 0.82 CYP2D6 (0.42) CYP2D6KMT2AALDH1A1KDM4ENPSR1
SCHEMBL21384531 0.82 L3MBTL1 (0.39) KMT2AALDH1A1TP53L3MBTL1POLB
SCHEMBL21401562 0.82 L3MBTL1 (0.39) KMT2AALDH1A1TP53L3MBTL1POLB
SCHEMBL9852971 0.81 CYP2D6 (0.62) CYP2D6KMT2AALDH1A1KDM4ENPSR1
SCHEMBL23453563 0.80 CYP2D6 (0.49) CYP2D6KMT2ATP53CYP1A2MEN1
SCHEMBL23453503 0.79 CYP2D6 (0.50) CYP2D6KMT2AALDH1A1NPSR1TP53
SCHEMBL21682372 0.78 CYP2D6 (0.49) CYP2D6ALDH1A1NPSR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12398119-B2 Piperazine azaspiro derivatives PFIZER INC. (US) 2025-08-26 — — US disclosed
CN-112154145-B Piperazine azaspiro derivatives 辉瑞大药厂 2023-10-17 — — CN disclosed
US-20230192654-A1 PIPERAZINE AZASPIRO DERIVATIVES PFIZER INC. 2023-06-22 — — US disclosed
US-20230192654-A1 PIPERAZINE AZASPIRO DERIVATIVES PFIZER INC. 2023-06-22 — — US disclosed
US-20230192654-A1 PIPERAZINE AZASPIRO DERIVATIVES PFIZER INC. 2023-06-22 — — US disclosed
US-11524954-B2 Piperazine azaspiro derivatives PFIZER INC. (US) 2022-12-13 — — US disclosed
US-11524954-B2 Piperazine azaspiro derivatives PFIZER INC. (US) 2022-12-13 — — US disclosed
US-20210024497-A1 PIPERAZINE AZASPIRO DERIVAVES PFIZER INC. 2021-01-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192654-A1 PIPERAZINE AZASPIRO DERIVATIVES CHRM1, CHRM2, CHRM5 CYP2D6 360/4885KMT2A 597/4885ALDH1A1 1350/4885
US-12398119-B2 Piperazine azaspiro derivatives CHRM1, CHRM2, CHRM5 CYP2D6 360/4885KMT2A 597/4885ALDH1A1 1350/4885
US-11524954-B2 Piperazine azaspiro derivatives CHRM1, CHRM2, CHRM5 CYP2D6 360/4885KMT2A 597/4885ALDH1A1 1350/4885
US-20210024497-A1 PIPERAZINE AZASPIRO DERIVAVES CHRM1, CHRM2, CHRM5 CYP2D6 259/4885KMT2A 535/4885ALDH1A1 906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.