Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 2/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30645558 | 1.00 | HTR1A (0.58) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| SCHEMBL19579571 | 0.81 | HTR1A (0.64) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| SCHEMBL30645552 | 0.81 | HTR1A (0.64) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| SCHEMBL30645557 | 0.81 | HTR1A (0.56) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| SCHEMBL21384461 | 0.81 | HTR1A (0.56) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL30618993 | 0.79 | HTR1A (0.52) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| SCHEMBL26086904 | 0.78 | EPHX2 (0.63) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| SCHEMBL31651660 | 0.78 | EPHX2 (0.62) | HTR1ASLC6A2EPHX2HTR2AHTR2C | |
| SCHEMBL2089531 | 0.76 | ADRB1 (0.63) | HTR1ASLC6A2SLC6A4HTR7ADRB1 | |
| SCHEMBL30952436 | 0.76 | ADRB1 (0.63) | HTR1ASLC6A2SLC6A4HTR7ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398119-B2 | Piperazine azaspiro derivatives | PFIZER INC. (US) | 2025-08-26 | — | — | US | disclosed |
| CN-112154145-B | Piperazine azaspiro derivatives | 辉瑞大药厂 | 2023-10-17 | — | — | CN | disclosed |
| EP-4219464-A1 | PIPERAZINE AZASPIRO DERIVAVES | Pfizer Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20230192654-A1 | PIPERAZINE AZASPIRO DERIVATIVES | PFIZER INC. | 2023-06-22 | — | — | US | disclosed |
| EP-3768669-B1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER (US) | 2023-01-25 | — | — | EP | disclosed |
| US-11524954-B2 | Piperazine azaspiro derivatives | PFIZER INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210024497-A1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER INC. | 2021-01-28 | — | — | US | disclosed |
| EP-3768669-A1 | PIPERAZINE AZASPIRO DERIVAVES | Pfizer Inc (US) | 2021-01-27 | — | — | EP | disclosed |
| CN-112154145-A | Piperazine azaspiro derivatives | 辉瑞大药厂 | 2020-12-29 | — | — | CN | disclosed |
| WO-2019183636-A1 | PIPERAZINE AZASPIRO DERIVAVES | PFIZER INC. (US) | 2019-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192654-A1 | PIPERAZINE AZASPIRO DERIVATIVES | CHRM1, CHRM2, CHRM5 | HTR1A 212/4885SLC6A2 380/4885EPHX2 1113/4885 |
| US-12398119-B2 | Piperazine azaspiro derivatives | CHRM1, CHRM2, CHRM5 | HTR1A 212/4885SLC6A2 380/4885EPHX2 1113/4885 |
| US-11524954-B2 | Piperazine azaspiro derivatives | CHRM1, CHRM2, CHRM5 | HTR1A 212/4885SLC6A2 380/4885EPHX2 1113/4885 |
| US-20210024497-A1 | PIPERAZINE AZASPIRO DERIVAVES | CHRM1, CHRM2, CHRM5 | HTR1A 127/4885SLC6A2 433/4885EPHX2 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.