Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 5/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | BCR | P11274 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10706017 | 0.81 | CHRM5 (0.63) | CYP1B1CYP1A1PTGS2ALDH1A1NQO2 | |
| SCHEMBL27885399 | 0.79 | CHRM5 (0.72) | PTGS2ALDH1A1NQO2CYP19A1CYP1A2 | |
| SCHEMBL31182402 | 0.79 | CHRM5 (0.72) | PTGS2ALDH1A1NQO2CYP19A1CYP1A2 | |
| SCHEMBL14950238 | 0.79 | CHRM5 (0.72) | PTGS2ALDH1A1NQO2CYP19A1CYP1A2 | |
| SCHEMBL5313268 | 0.78 | MKNK2 (0.53) | CYP1B1CYP1A1PTGS2CYP1A2CHRM5 | |
| SCHEMBL13128174 | 0.77 | CYP1B1 (0.56) | CYP1B1CYP1A1PTGS2ALDH1A1NQO2 | |
| SCHEMBL3657928 | 0.77 | GRIN2D (0.58) | PTGS2ALDH1A1CYP1A2KDM4EGAA | |
| SCHEMBL3971293 | 0.77 | GRIN2D (0.58) | PTGS2ALDH1A1CYP1A2KDM4EGAA | |
| SCHEMBL23634786 | 0.76 | LMNA (0.54) | CYP1B1CYP1A1ALDH1A1CYP1A2TUBB4A | |
| SCHEMBL15986625 | 0.74 | CYP1B1 (0.52) | CYP1B1CYP1A1PTGS2ALDH1A1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008292-B2 | FGFR4 inhibitor and preparation method and use thereof | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2021-05-18 | — | — | US | disclosed |
| EP-3543227-B1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2020-12-30 | — | — | EP | disclosed |
| US-20200062716-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2020-02-27 | — | — | US | disclosed |
| EP-3543227-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2019-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008292-B2 | FGFR4 inhibitor and preparation method and use thereof | FGFR4, FGFR1, FGFR2 | CYP1B1 556/4885CYP1A1 1432/4885PTGS2 3992/4885 |
| US-20200062716-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FGFR4, FGFR1, FGFR2 | CYP1B1 556/4885CYP1A1 1432/4885PTGS2 3992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.