Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386595 | 0.89 | GAA (0.36) | GAAALDH1A1KDM4ECYP3A4HMGCR | |
| SCHEMBL12311289 | 0.72 | ACHE (0.42) | GAAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL12348450 | 0.71 | GAA (0.44) | GAAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL20094055 | 0.69 | GAA (0.39) | GAAALDH1A1KDM4EMAPTCYP3A4 | |
| SCHEMBL3475991 | 0.69 | CYP1A1 (0.58) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL1359479 | 0.69 | ALDH1A1 (0.50) | GAAALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL3475990 | 0.69 | CYP1A1 (0.58) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL1822491 | 0.67 | GAA (0.47) | GAAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL21386608 | 0.66 | GAA (0.33) | GAAALDH1A1KDM4EPRKDCNFE2L2 | |
| SCHEMBL19708742 | 0.65 | GAA (0.43) | GAAALDH1A1KDM4EMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543227-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2019-09-25 | — | — | EP | disclosed |