Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 13/20 | 0.61 |
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | JAK3 | P52333 | 5/20 | 0.51 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386699 | 0.92 | BTK (0.59) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386722 | 0.92 | BTK (0.63) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386733 | 0.90 | BTK (0.62) | BTKEGFRJAK3ITK | |
| SCHEMBL21386780 | 0.90 | BTK (0.66) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386777 | 0.90 | BTK (0.75) | BTKEGFRJAK3JAK1 | |
| SCHEMBL21386767 | 0.89 | BTK (0.61) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386739 | 0.88 | BTK (0.54) | BTKEGFRJAK3ITK | |
| SCHEMBL21386776 | 0.88 | BTK (0.57) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386770 | 0.87 | BTK (0.66) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL23735117 | 0.86 | BTK (0.55) | BTKEGFRJAK3ITKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543239-A1 | SELECTIVE BRUTON'S TYROSINE KINASE INHIBITOR AND USE THEREOF | Hangzhou Hertz Pharmaceutical Co., Ltd. (CN) | 2019-09-25 | — | — | EP | disclosed |