Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | JAK3 | P52333 | 7/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386780 | 0.93 | BTK (0.66) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386777 | 0.93 | BTK (0.75) | BTKEGFRJAK3JAK1BLK | |
| SCHEMBL21386767 | 0.89 | BTK (0.61) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386782 | 0.88 | BTK (0.67) | BTKEGFRITK | |
| SCHEMBL21386733 | 0.87 | BTK (0.62) | BTKEGFRJAK3ITKBLK | |
| SCHEMBL21386736 | 0.87 | BTK (0.61) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386722 | 0.86 | BTK (0.63) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL18877721 | 0.85 | BTK (0.86) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL14228143 | 0.85 | BTK (0.86) | BTKEGFRJAK3ITKJAK1 | |
| SCHEMBL21386699 | 0.85 | BTK (0.59) | BTKEGFRJAK3ITKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543239-A1 | SELECTIVE BRUTON'S TYROSINE KINASE INHIBITOR AND USE THEREOF | Hangzhou Hertz Pharmaceutical Co., Ltd. (CN) | 2019-09-25 | — | — | EP | disclosed |