Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387529 | 0.90 | KIT (0.49) | KITCNR1CNR2ALDH1A1RAB9A | |
| SCHEMBL21387453 | 0.85 | KIT (0.41) | KITTSHRMAPTTP53S1PR1 | |
| SCHEMBL21387395 | 0.81 | CNR1 (0.48) | KITCNR1CNR2ALDH1A1RAB9A | |
| SCHEMBL21387497 | 0.79 | KIT (0.47) | KITCNR1CNR2ALDH1A1RAB9A | |
| SCHEMBL21387522 | 0.79 | KIT (0.45) | KITCNR1CNR2MAPTTP53 | |
| SCHEMBL21387356 | 0.78 | CNR1 (0.45) | KITCNR1CNR2ALDH1A1RAB9A | |
| SCHEMBL22280284 | 0.76 | ALDH1A1 (0.55) | ALDH1A1RAB9ATSHRRECQLMAPT | |
| SCHEMBL21387469 | 0.75 | NR1H4 (0.57) | KITRAB9A | |
| SCHEMBL20844832 | 0.75 | KIT (0.53) | KITRAB9ALMNA | |
| SCHEMBL22280507 | 0.74 | CNR1 (0.46) | KITCNR1CNR2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751104-B1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | NOVARTIS AG (CH) | 2019-09-25 | — | — | EP | disclosed |