Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280458 | 0.89 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL22280454 | 0.89 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL22280440 | 0.87 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL21387450 | 0.76 | KIT (0.46) | ALDH1A1SMN1; SMN2RAB9ATSHRRECQL | |
| SCHEMBL19033693 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL22280507 | 0.76 | CNR1 (0.46) | ALDH1A1RAB9ANPC1TSHRRECQL | |
| SCHEMBL22280460 | 0.76 | RAB9A (0.51) | ALDH1A1SMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL10053485 | 0.75 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL22280438 | 0.75 | NPC1 (0.68) | RAB9ANPC1MAPTL3MBTL1CASP3 | |
| Trifluoroacetic Acid SCHEMBL31268701 | 0.74 | MITF (0.59) | ALDH1A1RAB9AMAPTATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |