Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 20/20 | 0.60 |
| ▸ | CTPS2 | Q9NRF8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387601 | 0.88 | CTPS1 (0.48) | CTPS1CTPS2 | |
| SCHEMBL21373752 | 0.85 | CTPS1 (0.76) | CTPS1 | |
| SCHEMBL21387691 | 0.84 | CTPS1 (0.74) | CTPS1 | |
| SCHEMBL21387603 | 0.84 | CTPS1 (0.49) | CTPS1 | |
| SCHEMBL21387638 | 0.83 | CTPS1 (0.51) | CTPS1 | |
| SCHEMBL21387609 | 0.82 | CTPS1 (0.71) | CTPS1 | |
| SCHEMBL21387729 | 0.82 | CTPS1 (0.46) | CTPS1 | |
| SCHEMBL21387707 | 0.81 | CTPS1 (0.75) | CTPS1 | |
| SCHEMBL21387604 | 0.80 | CTPS1 (0.69) | CTPS1 | |
| SCHEMBL21387674 | 0.80 | CTPS1 (0.72) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020245665-A1 | N-(4-(5-CHLOROPYRIDIN-3-YL)PHENYL)-2-(2-(CYCLOPROPANESULFONAMIDO)PYRIMIDIN-4-YL) BUTANAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HUMAN CTPS1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | STEP PHARMA S.A.S. (FR) | 2020-12-10 | — | — | WO | disclosed |
| WO-2019180244-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |