Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 18/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21373741 | 0.85 | CTPS1 (1.00) | CTPS1 | |
| SCHEMBL21387593 | 0.84 | CTPS1 (0.60) | CTPS1 | |
| SCHEMBL21387674 | 0.83 | CTPS1 (0.72) | CTPS1 | |
| SCHEMBL21387604 | 0.82 | CTPS1 (0.69) | CTPS1 | |
| SCHEMBL22762435 | 0.82 | CTPS1 (0.73) | CTPS1 | |
| SCHEMBL21387644 | 0.81 | CTPS1 (0.75) | CTPS1 | |
| SCHEMBL23139869 | 0.79 | CTPS1 (0.64) | CTPS1 | |
| SCHEMBL21387603 | 0.77 | CTPS1 (0.49) | CTPS1 | |
| SCHEMBL21387638 | 0.77 | CTPS1 (0.51) | CTPS1 | |
| SCHEMBL21387601 | 0.76 | CTPS1 (0.48) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |