Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 13/20 | 0.69 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387674 | 0.91 | CTPS1 (0.72) | CTPS1WNT3A | |
| SCHEMBL21387691 | 0.82 | CTPS1 (0.74) | CTPS1 | |
| SCHEMBL21373806 | 0.82 | CTPS1 (1.00) | CTPS1 | |
| SCHEMBL21387593 | 0.80 | CTPS1 (0.60) | CTPS1 | |
| SCHEMBL21387603 | 0.80 | CTPS1 (0.49) | CTPS1 | |
| SCHEMBL21387714 | 0.80 | CTPS1 (0.41) | CTPS1LMNA | |
| SCHEMBL21387638 | 0.79 | CTPS1 (0.51) | CTPS1 | |
| SCHEMBL21387729 | 0.78 | CTPS1 (0.46) | CTPS1 | |
| SCHEMBL21387731 | 0.74 | CTPS1 (0.72) | CTPS1WNT3A | |
| SCHEMBL21392071 | 0.68 | CTPS1 (0.31) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |