Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 12/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387637 | 0.81 | MAPK1 (0.45) | CTPS1NPSR1MAPTCYP2C9MAPK1 | |
| SCHEMBL21373711 | 0.79 | CTPS1 (0.54) | CTPS1 | |
| SCHEMBL21387725 | 0.79 | CTPS1 (0.44) | CTPS1NPSR1MAPTCYP2C9MAPK1 | |
| SCHEMBL21387640 | 0.78 | CTPS1 (0.52) | CTPS1 | |
| SCHEMBL21387688 | 0.75 | SYK (0.32) | — | |
| SCHEMBL21387600 | 0.69 | CTPS1 (0.31) | CTPS1 | |
| SCHEMBL22758565 | 0.69 | CTPS1 (0.37) | CTPS1NPSR1MAPTCYP2C9 | |
| SCHEMBL21392095 | 0.63 | CTPS1 (0.50) | CTPS1 | |
| Hydrochloric Acid SCHEMBL21384760 | 0.62 | CTPS1 (0.49) | CTPS1 | |
| SCHEMBL23173845 | 0.61 | TSHR (0.54) | MAPK1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |