Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 3/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387693 | 0.84 | SYK (0.43) | CTPS1SYK | |
| SCHEMBL21387688 | 0.78 | SYK (0.32) | SYK | |
| SCHEMBL21387640 | 0.76 | CTPS1 (0.52) | CTPS1 | |
| SCHEMBL21387636 | 0.75 | CTPS1 (0.39) | CTPS1 | |
| SCHEMBL21392081 | 0.74 | TAS2R14 (0.40) | SYKTAS2R14 | |
| SCHEMBL21387637 | 0.72 | MAPK1 (0.45) | CTPS1SYK | |
| SCHEMBL21387698 | 0.72 | HTR3A (0.32) | CTPS1 | |
| SCHEMBL21392071 | 0.71 | CTPS1 (0.31) | CTPS1 | |
| SCHEMBL22762464 | 0.70 | ATAD2 (0.41) | — | |
| SCHEMBL21387725 | 0.70 | CTPS1 (0.44) | CTPS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |