SCHEMBL21390745

SCHEMBL21390745

C=CCc1cccc(-c2nc(-c3ccccc3)nc(-c3nc(-c4cccnc4)nc(-c4nc(-c5ccccc5)nc(-c5ccccc5)n4)n3)n2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GBA1 P04062 5/20 0.44
PDE5A O76074 7/20 0.43
CYP1A2 P05177 5/20 0.43
CYP3A4 P08684 5/20 0.43
CYP2D6 P10635 5/20 0.43
CYP2C19 P33261 4/20 0.43
ALDH1A1 P00352 4/20 0.43
TSHR P16473 4/20 0.43
CLK4 Q9HAZ1 4/20 0.43
MAPK1 P28482 3/20 0.43
HSD17B10 Q99714 3/20 0.43
USP2 O75604 3/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
LMNA P02545 2/20 0.43
TP53 P04637 1/20 0.43
PTGS1 P23219 1/20 0.43
TBXAS1 P24557 1/20 0.43
PTGS2 P35354 1/20 0.43
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21390491 0.91 CYP19A1 (0.43) GBA1PDE5ACYP1A2CYP3A4CYP2D6
SCHEMBL21390292 0.90 CYP19A1 (0.44) GBA1PDE5ACYP1A2CYP3A4CYP2D6
SCHEMBL21390618 0.88 CYP19A1 (0.49) GBA1PDE5ACYP1A2CYP3A4CYP2D6
SCHEMBL21390636 0.86 CYP2A6 (0.46) GBA1PDE5ACYP1A2CYP3A4CYP2D6
SCHEMBL21390740 0.85 CYP19A1 (0.44) GBA1PDE5ACYP1A2CYP3A4CYP2D6
SCHEMBL21390604 0.84 PTGS2 (0.48) CYP3A4ALDH1A1TSHRMAPK1MEN1
SCHEMBL21390741 0.83 CYP2A6 (0.48) ALDH1A1TSHRHSD17B10MEN1LMNA
SCHEMBL21390634 0.83 CYP2A6 (0.48) ALDH1A1TSHRHSD17B10MEN1LMNA
SCHEMBL21390285 0.79 PRKCI (0.47) PDE5AHSD17B10PTGS1TBXAS1PTGS2
SCHEMBL21390728 0.76 MEN1 (0.47) CYP3A4ALDH1A1MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190292309-A1 HIGH POLYMER, MIXTURE CONTAINING SAME, COMPOSITION, ORGANIC ELECTRONIC COMPONENT, AND MONOMER FOR POLYMERIZATION GUANGZHOU CHINARAY OPTOELECTRONIC MATERIALS LTD. (CN) 2019-09-26 US disclosed