Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391106 | 0.87 | HDAC1 (0.37) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 | |
| SCHEMBL21390843 | 0.85 | CYP19A1 (0.33) | HDAC1CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL21390845 | 0.85 | HDAC1 (0.40) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 | |
| SCHEMBL21390840 | 0.84 | HDAC1 (0.35) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 | |
| SCHEMBL21390841 | 0.83 | HDAC1 (0.35) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 | |
| SCHEMBL21391026 | 0.80 | HDAC1 (0.37) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 | |
| SCHEMBL18791675 | 0.79 | EGFR (0.42) | CYP11B2CYP11B1CYP19A1ADRB1ADRA2A | |
| SCHEMBL23132031 | 0.79 | CYP11B2 (0.41) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 | |
| SCHEMBL21390674 | 0.77 | ALK (0.37) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 | |
| SCHEMBL21391041 | 0.77 | HDAC1 (0.36) | HDAC1CYP11B2CYP11B1CYP19A1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |