Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391106 | 0.87 | HDAC1 (0.37) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL21390842 | 0.85 | HDAC1 (0.36) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL21391026 | 0.84 | HDAC1 (0.37) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL21390840 | 0.84 | HDAC1 (0.35) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL21390841 | 0.83 | HDAC1 (0.35) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL21390674 | 0.81 | ALK (0.37) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL21391041 | 0.80 | HDAC1 (0.36) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL23132031 | 0.79 | CYP11B2 (0.41) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 | |
| SCHEMBL18779189 | 0.78 | ALK (0.43) | CYP11B1CYP11B2CYP19A1ADRB1ADRA2A | |
| SCHEMBL21391156 | 0.78 | ADRB1 (0.35) | HDAC1CYP11B1CYP11B2CYP19A1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |