Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390988 | 0.83 | PDE2A (0.32) | PDE2AAGTR1AGTR2 | |
| SCHEMBL21390834 | 0.80 | PDE4B (0.35) | PDE2AIRAK4TP53 | |
| SCHEMBL19277997 | 0.79 | PDE2A (0.38) | PDE2AL3MBTL1TRPV1IRAK4TP53 | |
| SCHEMBL21390832 | 0.78 | PDE2A (0.33) | PDE2AIRAK4 | |
| SCHEMBL21390780 | 0.78 | IRAK4 (0.31) | PDE2AIRAK4 | |
| SCHEMBL21390829 | 0.75 | CNR2 (0.38) | — | |
| SCHEMBL21391146 | 0.75 | — | — | |
| SCHEMBL21390917 | 0.73 | PDE2A (0.30) | PDE2A | |
| SCHEMBL19277995 | 0.73 | PDE2A (0.36) | PDE2ATRPV1IRAK4 | |
| SCHEMBL21390968 | 0.72 | PDE2A (0.33) | PDE2AIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |