Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 14/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 13/20 | 0.37 |
| ▸ | CDK1 | P06493 | 8/20 | 0.37 |
| ▸ | CDK7 | P50613 | 8/20 | 0.37 |
| ▸ | CDK9 | P50750 | 8/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31434392 | 0.77 | CDK4 (0.39) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL28477463 | 0.77 | CDK4 (0.39) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL21354647 | 0.73 | KCNQ3 (0.35) | — | |
| SCHEMBL21391181 | 0.72 | KHK (0.36) | CDK4CDK6CCND3CCND1 | |
| SCHEMBL27254418 | 0.72 | JAK2 (0.33) | — | |
| SCHEMBL21354733 | 0.71 | JAK2 (0.33) | EGLN2 | |
| SCHEMBL21390936 | 0.71 | — | — | |
| SCHEMBL21354738 | 0.70 | TYK2 (0.34) | EGLN2 | |
| SCHEMBL410438 | 0.63 | TTR (0.41) | GRM5EGLN2 | |
| SCHEMBL25189727 | 0.63 | KDM1A (0.34) | GRM5EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |