Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391030 | 0.72 | CDK4 (0.40) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL23731147 | 0.63 | KHK (0.35) | KHKTRPV4CYP11B1CYP11B2 | |
| SCHEMBL19009014 | 0.63 | TRPV4 (0.45) | KHKTRPV4CYP11B1CYP11B2 | |
| SCHEMBL30493379 | 0.61 | TRPV4 (0.43) | KHKTRPV4CYP11B1CYP11B2 | |
| SCHEMBL25436881 | 0.61 | TRPV4 (0.43) | KHKTRPV4CYP11B1CYP11B2 | |
| SCHEMBL12775444 | 0.61 | KHK (0.39) | KHKTRPV4CYP11B1CYP11B2 | |
| SCHEMBL12143428 | 0.60 | KHK (0.44) | KHKTRPV4CYP11B1CYP11B2 | |
| SCHEMBL19803240 | 0.60 | TRPV4 (0.34) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL31214295 | 0.60 | KHK (0.62) | KHKTRPV4CYP11B1CYP11B2 | |
| SCHEMBL13483842 | 0.59 | TRPV4 (0.50) | KHKTRPV4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |