Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28039609 | 0.88 | PNMT (0.42) | TRPA1DRD2DRD3PNMTKDM1A | |
| SCHEMBL11017385 | 0.78 | TRPA1 (0.44) | TRPA1DRD2DRD3PNMTKDM1A | |
| SCHEMBL24375978 | 0.75 | — | — | |
| SCHEMBL29741121 | 0.73 | PNMT (0.60) | DRD2DRD3PNMTKDM1ACYP11B2 | |
| SCHEMBL3363261 | 0.73 | PNMT (0.60) | DRD2DRD3PNMTKDM1ACYP11B2 | |
| Hydrochloric Acid SCHEMBL15205820 | 0.71 | PNMT (0.58) | DRD2DRD3PNMTKDM1ACYP11B2 | |
| SCHEMBL17350029 | 0.71 | PNMT (0.58) | DRD2DRD3PNMTKDM1ACYP11B2 | |
| SCHEMBL7647780 | 0.70 | PNMT (0.44) | TRPA1DRD2DRD3PNMTKDM1A | |
| SCHEMBL12471274 | 0.70 | TSHR (0.48) | TRPA1NOS3NOS1NOS2MAOA | |
| SCHEMBL8222195 | 0.69 | PNMT (0.60) | DRD2DRD3PNMTKDM1ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |