Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.33 |
| ▸ | JAK3 | P52333 | 9/20 | 0.33 |
| ▸ | JAK2 | O60674 | 9/20 | 0.33 |
| ▸ | TYK2 | P29597 | 8/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391086 | 0.86 | AR (0.33) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL21390892 | 0.82 | KDM4E (0.33) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL21391098 | 0.82 | JAK1 (0.31) | JAK1 | |
| SCHEMBL30315379 | 0.81 | ALK (0.36) | JAK1JAK3JAK2TYK2S1PR1 | |
| SCHEMBL21354691 | 0.81 | ALK (0.36) | JAK1JAK3JAK2TYK2S1PR1 | |
| SCHEMBL21390682 | 0.77 | JAK1 (0.32) | JAK1 | |
| SCHEMBL21390679 | 0.77 | TNF (0.36) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL21390808 | 0.76 | JAK2 (0.33) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL21390890 | 0.75 | PLA2G1B (0.33) | JAK1JAK2 | |
| SCHEMBL21390891 | 0.74 | TNF (0.36) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |