Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | LITAF | Q99732 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | IDH1 | O75874 | 5/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | APLNR | P35414 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.30 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390679 | 0.97 | TNF (0.36) | TNFLITAFHCRTR2HCRTR1IDH1 | |
| SCHEMBL21390924 | 0.84 | HTR3A (0.34) | TNFLITAFPDE10AJAK1APLNR | |
| SCHEMBL21354627 | 0.79 | EGFR (0.41) | TNFLITAFHCRTR2HCRTR1IDH1 | |
| SCHEMBL21391174 | 0.75 | JAK1 (0.35) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21391098 | 0.75 | JAK1 (0.31) | IDH1JAK1 | |
| SCHEMBL21391171 | 0.75 | BRD4 (0.39) | IDH1 | |
| SCHEMBL21391073 | 0.75 | PDE10A (0.37) | PDE10A | |
| SCHEMBL21354685 | 0.74 | EGFR (0.42) | TNFLITAFIDH1EGFRHCAR1 | |
| SCHEMBL21391074 | 0.74 | RORC (0.30) | — | |
| SCHEMBL21390969 | 0.73 | TNF (0.38) | TNFLITAFHCRTR2HCRTR1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |