Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 5/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 5/20 | 0.31 |
| ▸ | JAK2 | O60674 | 4/20 | 0.31 |
| ▸ | TYK2 | P29597 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391096 | 0.86 | JAK1 (0.33) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL21390870 | 0.84 | JAK1 (0.30) | JAK1 | |
| SCHEMBL21390892 | 0.80 | KDM4E (0.33) | JAK1JAK3JAK2TYK2KDM4E | |
| SCHEMBL29701147 | 0.79 | EGFR (0.37) | ARKDM4EALDH1A1HPGDHIF1A | |
| SCHEMBL29701148 | 0.79 | EGFR (0.37) | ARKDM4EALDH1A1HPGDHIF1A | |
| SCHEMBL21354707 | 0.79 | EGFR (0.37) | ARKDM4EALDH1A1HPGDHIF1A | |
| SCHEMBL21391174 | 0.77 | JAK1 (0.35) | JAK1JAK3JAK2TYK2KDM4E | |
| SCHEMBL21391078 | 0.77 | KDM4E (0.33) | JAK1JAK3JAK2TYK2KDM4E | |
| SCHEMBL21391067 | 0.77 | KDM4E (0.32) | JAK1JAK3JAK2TYK2KDM4E | |
| SCHEMBL21390924 | 0.76 | HTR3A (0.34) | JAK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |