SCHEMBL21392021

SCHEMBL21392021

CC(C)(C)c1ccc(N(c2ccc(-c3cc(-c4ccccc4)cs3)cc2)c2ccc(C(C)(C)C)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B2 P37059 6/20 0.47
HSD17B1 P14061 5/20 0.47
CYP3A4 P08684 2/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C19 P33261 1/20 0.41
PTGES O14684 1/20 0.38
ALOX5 P09917 1/20 0.38
MMP12 P39900 2/20 0.38
KIF11 P52732 3/20 0.38
DHODH Q02127 1/20 0.36
DYRK1A Q13627 1/20 0.36
DYRK1B Q9Y463 1/20 0.36
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36
TNF P01375 1/20 0.35
NOD1 Q9Y239 1/20 0.35
CYP19A1 P11511 1/20 0.34
MMP2 P08253 1/20 0.34
MMP8 P22894 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27961806 0.91 HSD17B2 (0.54) HSD17B2HSD17B1CYP3A4CYP2C9CYP2D6
SCHEMBL21012146 0.87 APP (0.38) HSD17B2HSD17B1CYP3A4CYP2C9CYP2D6
SCHEMBL21392015 0.83 KCNH2 (0.39) HSD17B2HSD17B1CYP3A4CYP2D6CYP2C19
SCHEMBL18372419 0.83 KIF11 (0.48) HSD17B2CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL16344297 0.83 KIF11 (0.48) HSD17B2CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL14447688 0.83 KIF11 (0.48) HSD17B2CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL17849332 0.83 KIF11 (0.48) HSD17B2CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL15641801 0.82 PTGES (0.43) HSD17B2CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL19862775 0.81 KIF11 (0.47) HSD17B2CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL21012117 0.80 APP (0.35) CYP3A4CYP2C9CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11094474-B2 Photoelectric conversion element, dye-sensitized solar cell, metal complex dye, dye composition, and oxide semiconductor electrode FUJIFILM CORPORATION (JP) 2021-08-17 US disclosed
US-20190295779-A1 PHOTOELECTRIC CONVERSION ELEMENT, DYE-SENSITIZED SOLAR CELL, METAL COMPLEX DYE, DYE COMPOSITION, AND OXIDE SEMICONDUCTOR ELECTRODE FUJIFILM CORPORATION (JP) 2019-09-26 US disclosed