Sugi Predict

Sugi Predict / Compounds / SCHEMBL2139236

SCHEMBL2139236

SCHEMBL2139236

Clc1ccccc1-c1nc2ccccc2s1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 12/20 0.64
▸ RAB9A P51151 11/20 0.64
▸ NPC1 O15118 9/20 0.64
▸ ALDH1A1 P00352 9/20 0.64
▸ MAPT P10636 8/20 0.64
▸ GAA P10253 7/20 0.64
▸ SMN1; SMN2 Q16637 6/20 0.64
▸ L3MBTL1 Q9Y468 6/20 0.64
▸ MEN1 O00255 4/20 0.64
▸ KMT2A Q03164 4/20 0.64
▸ TDP1 Q9NUW8 4/20 0.64
▸ NPSR1 Q6W5P4 1/20 0.54
▸ POLB P06746 2/20 0.53
▸ HSD17B10 Q99714 2/20 0.51
▸ TP53 P04637 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ GLA P06280 4/20 0.51
▸ ILK Q13418 3/20 0.51
▸ HCRTR1 O43613 1/20 0.51
▸ S1PR2 O95136 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29829782 1.00 KDM4E (0.64) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL231307 0.86 KDM4E (0.75) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL12861180 0.85 RAB9A (0.59) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL7196366 0.85 RAB9A (0.63) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL12854008 0.84 KDM4E (0.72) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL28944530 0.84 RAB9A (0.62) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL2136152 0.83 EGFR (0.60) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL7584722 0.83 EGFR (0.54) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL792024 0.82 NPC1 (0.45) KDM4ERAB9ANPC1ALDH1A1MAPT
SCHEMBL1977551 0.80 MAPT (0.65) KDM4ERAB9ANPC1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111793040-B Preparation method of 2-substituted benzothiazole 太原理工大学 2023-01-03 — — CN disclosed
CN-109265409-B Synthesis method of 2-substituted benzoxazole, 2-substituted benzothiazole and derivatives thereof 重庆医科大学 2022-09-02 — — CN disclosed
WO-2021261851-A1 COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT USING SAME, AND ELECTRONIC DEVICE COMPRISING SAME ORGANIC ELECTRIC ELEMENT 덕산네오룩스 주식회사 2021-12-30 — — WO disclosed
CN-111793040-A Preparation method of 2-substituted benzothiazole 太原理工大学 2020-10-20 — — CN disclosed
CN-109338402-A A kind of method of electro-catalysis benzo thioamide analog compound synthesis benzothiazole in water 福建医科大学 2019-02-15 — — CN disclosed
CN-109293599-A A kind of method of microwave radiation benzo thioamide analog compound synthesis benzothiazole in water phase 福建医科大学 2019-02-01 — — CN disclosed
CN-109265409-A A kind of synthetic method of the benzoxazoles that 2- replaces and benzothiazole and its derivative that 2- replaces 重庆医科大学 2019-01-25 — — CN disclosed
CN-104910098-B Synthesis method of 2-arylbenzothiazole compound 大连理工大学 2017-03-22 — — CN disclosed
CN-103992291-B Method for synthesizing 2-substituted benzothiazole derivative NANJING TECH UNIVERSITY (CN) 2016-02-10 — — CN disclosed
CN-104910098-A Synthesis method of 2-arylbenzothiazole compound UNIV DALIAN TECH 2015-09-16 — — CN disclosed
CN-103992291-A Method for synthesizing 2-substituted benzothiazole derivative NANJING UNIVERSITY OF TECHNOLOGY 2014-08-20 — — CN disclosed
US-8242278-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-14 — — US disclosed
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI (JP) 2012-04-26 — — US disclosed
EP-1473286-B1 PROCESS FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL CO (JP) 2009-11-04 — — EP disclosed
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI 2009-08-27 — — US disclosed
US-7554000-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-30 — — US disclosed
CN-1303043-C Process for producing biaryl compound SUMITOMO CHEMICAL CO (JP) 2007-03-07 — — CN disclosed
CN-1642879-A Process for preparing diaryl compounds SUMITOMO CHEMICAL CO (JP) 2005-07-20 — — CN disclosed
US-20050096471-A1 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-05-05 — — US disclosed
EP-1473286-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR KDM4E 3428/4885RAB9A 2254/4885NPC1 4102/4885
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR KDM4E 3428/4885RAB9A 2254/4885NPC1 4102/4885
US-20050096471-A1 Process for producing biaryl compound PPOX, CAT, TYR KDM4E 3428/4885RAB9A 2254/4885NPC1 4102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.