Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.32 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31438561 | 0.81 | NAMPT (0.39) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL19273667 | 0.79 | LOXL2 (0.39) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL30728748 | 0.78 | KDM4E (0.64) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL1329736 | 0.78 | KDM4E (0.64) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL17425264 | 0.76 | LOXL2 (0.41) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL459712 | 0.71 | LOXL2 (0.44) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL25201864 | 0.71 | KDM4C (0.42) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL24568249 | 0.70 | PREP (0.55) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL29269616 | 0.69 | LOXL2 (0.38) | ALDH1A1KDM4EGLAGAAL3MBTL1 | |
| SCHEMBL1883186 | 0.69 | ORAI1 (0.49) | ALDH1A1KDM4EGLAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |