Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 2/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31394019 | 0.81 | KDM4E (0.44) | KDM4EKMT2AHPGDALDH1A1HTT | |
| SCHEMBL20187567 | 0.80 | ATM (0.39) | KDM4EKMT2AHPGDALDH1A1HTT | |
| SCHEMBL29661969 | 0.79 | KDM4E (0.34) | KDM4EASPHKDM8ALDH1A1HCAR2 | |
| SCHEMBL20594415 | 0.79 | KMT2A (0.43) | KDM4EKMT2AASPHKDM8ALDH1A1 | |
| SCHEMBL20187507 | 0.79 | KDM4E (0.34) | KDM4EASPHKDM8ALDH1A1HCAR2 | |
| SCHEMBL23803677 | 0.79 | CHEK1 (0.36) | KDM4EKMT2AASPHKDM8ALDH1A1 | |
| SCHEMBL31331518 | 0.79 | CHEK1 (0.36) | KDM4EKMT2AASPHKDM8ALDH1A1 | |
| SCHEMBL29150280 | 0.78 | KDM4E (0.46) | KDM4EKMT2AHPGDALDH1A1HTT | |
| SCHEMBL23088380 | 0.78 | HTT (0.46) | KDM4EKMT2AHPGDALDH1A1HTT | |
| SCHEMBL23147036 | 0.77 | KDM4E (0.44) | KDM4EKMT2AHPGDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |