Sugi Predict

Sugi Predict / Compounds / SCHEMBL20187507

SCHEMBL20187507

SCHEMBL20187507

O=C(O)c1c(Br)cnc(Cl)c1F

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ ASPH Q12797 2/20 0.34
▸ KDM8 Q8N371 2/20 0.34
▸ KEAP1 Q14145 1/20 0.34
▸ NFE2L2 Q16236 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ ABL1 P00519 2/20 0.33
▸ BCR P11274 2/20 0.33
▸ KMO O15229 2/20 0.33
▸ NAPRT Q6XQN6 2/20 0.32
▸ BRD4 O60885 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ DPP4 P27487 1/20 0.31
▸ HCAR2 Q8TDS4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29661969 1.00 KDM4E (0.34) KDM4EALDH1A1SMN1; SMN2ASPHKDM8
SCHEMBL31368729 0.81 KMO (0.37) KDM4EALDH1A1SMN1; SMN2ASPHKDM8
SCHEMBL31267942 0.80 TSHR (0.36) KDM4EALDH1A1MAPK1LMNA
SCHEMBL20187643 0.80 TSHR (0.36) KDM4EALDH1A1MAPK1LMNA
SCHEMBL21393836 0.79 KDM4E (0.44) KDM4EALDH1A1SMN1; SMN2ASPHKDM8
SCHEMBL23089317 0.78 ALDH1A1 (0.42) KDM4EALDH1A1SMN1; SMN2MAPK1NAPRT
SCHEMBL31368738 0.78 MAPK1 (0.46) KDM4EALDH1A1SMN1; SMN2ASPHKDM8
SCHEMBL15644973 0.76 SSTR4 (0.35) ALDH1A1LMNA
SCHEMBL26982465 0.75 ALDH1A1 (0.33) KDM4EALDH1A1SMN1; SMN2MAPK1NAPRT
SCHEMBL22866408 0.75 BRD4 (0.32) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724441-A1 ISOINDOLINONE AND DIHYDROPYRROLOPRIDINONE COMPOUNDS AND USES THEREOF Revir Therapeutics, Inc. (US) 2026-04-15 — — EP disclosed
EP-3768260-B1 OXADIAZOLE COMPOUNDS AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS HOFFMANN LA ROCHE (CH) 2025-10-08 — — EP disclosed
US-20250122184-A1 OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS GENENTECH, INC. (US) 2025-04-17 — — US disclosed
US-12202824-B2 Oxadiazole transient receptor potential channel inhibitors GENENTECH, INC. (US) 2025-01-21 — — US disclosed
WO-2024251212-A1 ISOINDOLINONE AND DIHYDROPYRROLOPRIDINONE COMPOUNDS AND USES THEREOF REVIR THERAPEUTICS, INC. (US) 2024-12-12 — — WO disclosed
WO-2024251211-A1 COMPOSITIONS, METHODS, AND SYSTEMS FOR MODULATING SPLICING OF MSH3 REVIR THERAPEUTICS, INC. (US) 2024-12-12 — — WO disclosed
CN-114269756-B 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E 效应疗法股份有限公司 2024-05-14 — — CN disclosed
US-11655245-B2 Oxadiazole transient receptor potential channel inhibitors GENENTECH, INC. (US) 2023-05-23 — — US disclosed
US-11655245-B2 Oxadiazole transient receptor potential channel inhibitors GENENTECH, INC. (US) 2023-05-23 — — US disclosed
US-11655245-B2 Oxadiazole transient receptor potential channel inhibitors GENENTECH, INC. (US) 2023-05-23 — — US disclosed
EP-3544979-A1 OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS H. Hoffnabb-La Roche Ag (CH) 2019-10-02 — — EP disclosed
WO-2019182925-A1 OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS GENENTECH, INC. (US) 2019-09-26 — — WO disclosed
WO-2019182925-A1 OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS GENENTECH, INC. (US) 2019-09-26 — — WO disclosed
US-20190284179-A1 OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS GENENTECH, INC. (US) 2019-09-19 — — US disclosed
US-20190284179-A1 OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS GENENTECH, INC. (US) 2019-09-19 — — US disclosed
US-20190284189-A1 OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS GENENTECH, INC. (US) 2019-09-19 — — US disclosed
US-20190284189-A1 OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS GENENTECH, INC. (US) 2019-09-19 — — US disclosed
CN-110225911-A Oxadiazolone transient receptor potential channel inhibitors 豪夫迈·罗氏有限公司 2019-09-10 — — CN disclosed
WO-2018096159-A1 OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2018-05-31 — — WO disclosed
WO-2018096159-A1 OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2018-05-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12202824-B2 Oxadiazole transient receptor potential channel inhibitors TRPA1, TRPV1, TRPV3 KDM4E 4048/4885ALDH1A1 721/4885SMN1; SMN2 1161/4885
US-11655245-B2 Oxadiazole transient receptor potential channel inhibitors TRPA1, TRPV1, P2RX3 KDM4E 3914/4885ALDH1A1 665/4885SMN1; SMN2 1218/4885
US-20190284189-A1 OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS TRPA1, TRPV1, TRPV3 KDM4E 4296/4885ALDH1A1 319/4885SMN1; SMN2 1207/4885
US-20190284179-A1 OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS TRPA1, TRPV1, TRPV3 KDM4E 4048/4885ALDH1A1 721/4885SMN1; SMN2 1161/4885
US-20250122184-A1 OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS TRPA1, TRPV1, TRPV3 KDM4E 4048/4885ALDH1A1 721/4885SMN1; SMN2 1161/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.