Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29356936 | 1.00 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL29356925 | 0.91 | GCK (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL21394784 | 0.91 | GCK (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL21394550 | 0.89 | KDM4E (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1CREBBP | |
| SCHEMBL29353782 | 0.89 | KDM4E (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1CREBBP | |
| SCHEMBL21384386 | 0.88 | TP53 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL29358552 | 0.88 | TP53 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL21394825 | 0.88 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL21394976 | 0.88 | KDM4E (0.41) | ALDH1A1CREBBPKDM4ECXCR2GCK | |
| SCHEMBL29356860 | 0.88 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084800-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084801-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112312913-B | Compounds and uses thereof | 詹森药业有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-114174273-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-112312913-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |