Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29356925 | 0.91 | GCK (0.44) | KDM4ECREBBPDEGS1RXFP1GCK | |
| SCHEMBL21394784 | 0.91 | GCK (0.44) | KDM4ECREBBPDEGS1RXFP1GCK | |
| SCHEMBL21395178 | 0.89 | CYP11B1 (0.51) | KDM4ECREBBPCYP11B1CYP11B2DEGS1 | |
| SCHEMBL29353782 | 0.89 | KDM4E (0.51) | KDM4ECREBBPDEGS1RXFP1GCK | |
| SCHEMBL21394550 | 0.89 | KDM4E (0.51) | KDM4ECREBBPDEGS1RXFP1GCK | |
| SCHEMBL21394636 | 0.88 | F10 (0.43) | CREBBPDEGS1CYP3A4F10ALDH1A1 | |
| SCHEMBL29356936 | 0.88 | NPC1 (0.46) | KDM4ECREBBPDEGS1GCKNTRK1 | |
| SCHEMBL21394601 | 0.88 | NPC1 (0.46) | KDM4ECREBBPDEGS1GCKNTRK1 | |
| SCHEMBL21394480 | 0.86 | MAPT (0.44) | KDM4ECREBBPDEGS1RXFP1GCK | |
| SCHEMBL21384385 | 0.86 | CREBBP (0.42) | KDM4ECREBBPDEGS1RXFP1GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |