Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21394932 | 0.94 | CHEK1 (0.42) | CHEK1GRM2 | |
| SCHEMBL21395016 | 0.90 | CHEK1 (0.40) | CHEK1CYP3A4GRM2TMPRSS4SIRT2 | |
| SCHEMBL21395150 | 0.89 | TMPRSS4 (0.43) | CHEK1CYP3A4NPC1TSHRRAB9A | |
| SCHEMBL21395032 | 0.89 | SMN1; SMN2 (0.42) | CYP3A4NPC1ALDH1A1PKMTSHR | |
| SCHEMBL21395078 | 0.87 | CHEK1 (0.48) | CHEK1GRM2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21395011 | 0.85 | GRM4 (0.43) | CHEK1GRM2TMPRSS4SIRT2 | |
| SCHEMBL21395002 | 0.84 | TMPRSS4 (0.41) | CYP3A4NPC1ALDH1A1PKMTSHR | |
| SCHEMBL21394947 | 0.83 | JUN (0.43) | NPC1ALDH1A1PKMTSHRRAB9A | |
| SCHEMBL21395154 | 0.82 | TMPRSS4 (0.44) | CYP3A4TMPRSS4SIRT2 | |
| SCHEMBL21394950 | 0.82 | CHEK1 (0.49) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |