Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29358537 | 1.00 | GCK (0.41) | GCKDEGS1KDM4ERARGCYP3A4 | |
| SCHEMBL21394784 | 0.91 | GCK (0.44) | GCKDEGS1KDM4ERARG | |
| SCHEMBL29356925 | 0.91 | GCK (0.44) | GCKDEGS1KDM4ERARG | |
| SCHEMBL21394648 | 0.89 | SIRT2 (0.43) | DEGS1CYP3A4 | |
| SCHEMBL21394655 | 0.87 | CYP3A4 (0.40) | GCKDEGS1CYP3A4 | |
| SCHEMBL29357122 | 0.87 | CREBBP (0.46) | GCKDEGS1 | |
| SCHEMBL21394857 | 0.87 | CREBBP (0.46) | GCKDEGS1 | |
| SCHEMBL21395151 | 0.85 | EP300 (0.40) | GCKDEGS1KDM4ERARG | |
| SCHEMBL21394990 | 0.85 | DEGS1 (0.41) | GCKDEGS1RARGCYP3A4 | |
| SCHEMBL21394550 | 0.84 | KDM4E (0.51) | GCKDEGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084800-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084801-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112312913-B | Compounds and uses thereof | 詹森药业有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-114174273-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-112312913-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |