Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 6/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21396417 | 0.84 | KDM4E (0.67) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL21396339 | 0.83 | KDM4E (0.66) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL21396337 | 0.79 | MAPT (0.62) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL19358904 | 0.77 | ALDH1A1 (0.70) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL21396317 | 0.77 | MAPT (0.60) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL21378466 | 0.76 | TP53 (0.56) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL21378462 | 0.76 | TP53 (0.56) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL19358928 | 0.76 | ALDH1A1 (0.70) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL20603251 | 0.74 | TP53 (0.64) | KDM4EMAPTALDH1A1HSD17B10TP53 | |
| SCHEMBL3816104 | 0.72 | KDM4E (0.70) | KDM4EMAPTALDH1A1HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019180686-A1 | IDO-TDO DUAL INHIBITOR AND RELATED METHODS OF USE | CMG PHARMACEUTICAL CO., LTD. (KR) | 2019-09-26 | — | — | WO | disclosed |