Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 8/20 | 0.45 |
| ▸ | CDK9 | P50750 | 8/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.45 |
| ▸ | CCNH | P51946 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665651 | 1.00 | CDK7 (0.45) | CDK7CDK9CCNT1CCNHCSNK1A1 | |
| SCHEMBL21397349 | 0.78 | BTK (0.41) | CDK7CDK9 | |
| SCHEMBL16665652 | 0.78 | BTK (0.41) | CDK7CDK9 | |
| SCHEMBL21397324 | 0.78 | CDK1 (0.45) | CDK7CDK9CCNT1CCNHCSNK1A1 | |
| SCHEMBL16665608 | 0.78 | CDK1 (0.45) | CDK7CDK9CCNT1CCNHCSNK1A1 | |
| SCHEMBL23336389 | 0.77 | BRD4 (0.45) | CYP3A4ALOX15HSD17B10TDP1CYP1A2 | |
| SCHEMBL21397411 | 0.76 | MAPK1 (0.37) | — | |
| SCHEMBL22252797 | 0.76 | CDK9 (0.62) | CDK7CDK9CCNT1CCNHCSNK1A1 | |
| SCHEMBL22228805 | 0.76 | CDK9 (0.62) | CDK7CDK9CCNT1CCNHCSNK1A1 | |
| SCHEMBL31500950 | 0.76 | CDK9 (0.62) | CDK7CDK9CCNT1CCNHCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190292167-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292167-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | CDK7, CDK3, CDK17 | CDK7 1/4885CDK9 8/4885CCNT1 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.