SCHEMBL21397429

SCHEMBL21397429

CC(C)(C)OC(=O)[C@@H]1c2ccc(F)cc2CC12CCNCC2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.37
NR3C2 P08235 2/20 0.35
MAPK1 P28482 1/20 0.32
USP2 O75604 2/20 0.32
CYP2D6 P10635 2/20 0.32
ALOX15 P16050 1/20 0.32
DPP8 Q6V1X1 1/20 0.32
DPP9 Q86TI2 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
TACR1 P25103 1/20 0.32
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21397469 0.91 DPP4 (0.37) DPP4NR3C2DPP8DPP9GABRA1
SCHEMBL23046130 0.81 NPY5R (0.36) DPP4NR3C2USP2CYP2D6ALOX15
SCHEMBL29891089 0.81 NPY5R (0.36) DPP4NR3C2USP2CYP2D6ALOX15
SCHEMBL29891133 0.75 RORC (0.37) DPP4DPP8DPP9KDM1AHTR2A
SCHEMBL23046128 0.75 RORC (0.37) DPP4DPP8DPP9KDM1AHTR2A
SCHEMBL28513992 0.75 DPP4 (0.38) DPP4USP2CYP2D6ALOX15DPP8
SCHEMBL21384094 0.71 DPP4 (0.40) DPP4USP2CYP2D6ALOX15CHRNB2
SCHEMBL21384063 0.71 DPP4 (0.40) DPP4MAPK1CHRNB2CHRNB4CHRNA3
SCHEMBL23046174 0.71 DPP4 (0.40) DPP4MAPK1CHRNB2CHRNB4CHRNA3
SCHEMBL30529384 0.71 DPP4 (0.40) DPP4MAPK1CHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019183367-A1 SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. (US) 2019-09-26 WO disclosed