Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21378603 | 0.87 | MAPT (0.53) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL21378605 | 0.87 | MAPT (0.53) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL21378569 | 0.87 | MAPT (0.45) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL20289586 | 0.87 | MAPT (0.45) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL19700726 | 0.87 | MAPT (0.45) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL19700725 | 0.87 | MAPT (0.45) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL20289632 | 0.86 | MAPT (0.44) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL18459333 | 0.84 | RAB9A (0.47) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL18459334 | 0.84 | RAB9A (0.47) | MAPTNPC1ALDH1A1MAPK1HTT | |
| SCHEMBL20289382 | 0.83 | MAPT (0.42) | MAPTNPC1ALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696665-B2 | Mutant IDH1 inhibitors | ELI LILLY AND COMPANY (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190292175-A1 | MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10696665-B2 | Mutant IDH1 inhibitors | IDH1, IDH3B, IDH3A | MAPT 3706/4885NPC1 1905/4885ALDH1A1 260/4885 |
| US-20190292175-A1 | MUTANT IDH1 INHIBITORS | IDH1, IDH3B, IDH3A | MAPT 3706/4885NPC1 1905/4885ALDH1A1 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.